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KMID : 0605719960020020075
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Journal of the Korean Society of Biological Therapies in Psychiatry
1996 Volume.2 No. 2 p.75 ~ p.79
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Potentiation of antidepressant effect of imipramine by repeated treatment with ethaverine
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Young-Hoon Kim
Sang-Kyeong Lee/Jae-Hong Kim/Sun-Hee Kim/Kyong-Tai Kim
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Abstract
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Daily treatment for 10 days with 20㎎/㎏ imipramine and 10㎎/㎏ ethaverine reduced the immobilization time in the behavioral despair test in rats. However, 10㎎/㎏ verapamil did not reduce it significantly. It was suggested that ethaverine concomitantly administered potentiated the long-term effect of imipramine on the reduction of the immobilization time. In a hall of those rats(3/6) which had been repeatedly treated with both 20㎎/㎏ imipramine and 10㎎/㎏ ethaverine, vigorous swimming was observed during most of the test time despite no increased motor activity in an open field observation. In a second experiment, ethaverine exhibited the tendency of dose-dependent reduction of the immobilization time. In conclusion the data suggest that ethaverine has a anti-immobility effect in the behavioral despair test in rats and that it can be useful in potentiating the antidepressant effect of imipramine clinically.
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KEYWORD
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Ethaverine, Verapamil, Imipramine, Calcium channel blocker, Behavioral despair test,
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